Ibrutinib 140mg tablets are indicated for the treatment of patients with mantle cell lymphoma (MCL) who have at least one prior therapy, chronic lymphocytic leukemia (CLL) / small lymphocytic lymphoma (SLL), chronic lymphocytic leukemia (CLL) / small lymphocytic. Lymphoma SLL), macroglobulinemia (WM) of Waldenström, marginal zone lymphoma (MZL) who require systemic therapy and receive at least one prior CD20-based therapy Has received.
Ibrutinib is also used to treat a certain problem that can occur after a stem cell transplant (chronic disease vs. host disease). It works by weakening your body’s defence system or immune system.
Ibrutinib 140mg tablets capsules belong to a class of drugs known as kinase inhibitors.
It works by slowing or stopping the growth of cancer cells.
The recommended dose for mantle cell lymphoma (MCL) and marginal zone lymphoma- 560 mg (four 140 mg capsules) once daily until disease progression or unacceptable toxicity.
The recommended dose for chronic lymphocytic leukemia (CLL) / small lymphocytic leukemia (SLL) and Waldenström macroglobulinemia – 420 mg (three 140 mm capsules) once daily for disease progression or unacceptable toxicity.
The recommended dose for chronic grafts versus hot disease is 420 mg (three 140mg capsules) orally once daily until progression, recurrence of an underlying malignancy, or unacceptable toxicity.
Take this medicine as mouth-watering (8 ounces or 240 ml) as directed by your doctor, usually once daily. Swallow the capsules and tablets whole. Do not open, break, or chew the capsule. Do not cut, crush or chew the tablets. Drink plenty of fluids while taking Ibruxen 140mg tablets unless otherwise instructed by your doctor.
The dosage is based on your medical condition, response to treatment and other medications you are taking.
Before using these Ibruxen 140mg tablets, tell your doctor or pharmacist your medical history, in particular: blood/bleeding problems, heart problems (eg rapid/irregular heartbeat, previous heart attack), high blood pressure, kidney. Problems, liver problems, high levels of blood uric acid.
Common side effects are diarrhoea, thrombocytopenia, anaemia, neutropenia, fatigue, musculoskeletal pain, upper respiratory tract infection, peripheral edema, nausea, dyspnea, injury, rash, constipation, vomiting, reduced appetite and abdominal pain.